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Title: Studies towards the total synthesis of Lactonamycin
Author: Board, Johnathan
ISNI:       0000 0001 3468 6328
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2007
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Work was performed towards the synthesis of the achiral portion of the antitumor antibiotic lactonamycin. It was proposed that this would be accessible via a novel cascade reaction utilising either transition metal, or radical protocols. A model system was devised, synthesised, and the cascade reaction successfully performed using radical chemistry. Upon heating the cascade precursor in a thermal decomposition study, it was found that the cyclisation proceeded via a thermal mechanism and that no radical or heavy metal additives were required. Investigations into this noyel cyclisat~on reaction were undertaken through the use of analogues and several reaction mechanisms postulated. Further work on aromatisation of the lactonamycin model system was undertaken and a possible synthesis of the achiral portion of lactonamycin proposed as a result.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available