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Title: Cell biology and regulation of angiotensin-converting enzyme 2
Author: Rushworth, Christopher Alan
ISNI:       0000 0001 3539 7974
Awarding Body: Leeds
Current Institution: University of Leeds
Date of Award: 2008
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The zinc metalloprotease angiotensin-converting enzyme 2 (ACE2) and its homologue, ACE, are the central enzymes of the renin-angiotensin system (RAS), which regulates blood pressure, electrolyte balance and fluid volume homeostasis. ACE2 is thought to counterbalance ACE-mediated angiotensin (Ang) II formation by converting this peptide into the vasodilator Ang-(l-7). Both enzymes are implicated in cardiac fimction, renal disease, diabetes, atherosclerosis and acute lung injury, with ACE2 also being the functional receptor for the coronavirus that is linked to severe acute respiratory syndrome (SARS).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available