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Title: Cell survival and cell death: Role of potassium channels in Alzheimer's disease
Author: Edwards, Joanna Marie
ISNI:       0000 0001 3440 0633
Awarding Body: Leeds
Current Institution: University of Leeds
Date of Award: 2008
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Amyloid beta protein (AP) is found in elevated levels in the brains of individuals with Alzheimer's disease, the increased levels of AP are thought to be a causative factor in the pronounced cortical atrophy that is observed post-mortem. Application of exogenous Apuo at physiological and pathological concentrations did not induce cell death in SH-SY5Y cells, differentiated SH-SY5Y cells nor in primary ortical neurone cultures when viability was measured using the Live/Dead cytotoxicity assay. Therefore, rather than a cytotoxic role of Ap this data suggests a more neuroprotective role.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available