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Title: Examining the role of the mismatch repair system : the barrier to non-homologous recombination in meiosis and mitosis
Author: Tittcomb, Kay
ISNI:       0000 0001 3533 8771
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2007
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Meiosis js a requirement of sexual reproduction. Prophase I of the first meiotic division is characterised by segregation of homologous chromosomes from one another and by the process of recombination. Homologous recombination, initiate by a DNA double strand break is a means by which the homologous chromosomes become physically linked to one another and can then correctly attach to the meiotic spindle. Choice of a suitable template for repair of the double strand break is vital to the integrity of the genome. The mismatch repair (MMR) system is an evolutionarily conserved repair process which acts to prevent potentially deleterious non-homologous recombination. To further investigate the relationship between the degree of chromosomal sequence homology, the frequency of meiotic recombination and the mismatch repair system, a novel assay for the detection of mature homeologous recombination products was developed and tested in meiosis and mitosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available