Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487514 |
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Title: | Genetic aspects of autoimmune diabetes with particular reference to the role of HLA | ||||
Author: | Britten, Abigail Caroline |
ISNI:
0000 0001 3480 5972
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Awarding Body: | University of Birmingham | ||||
Current Institution: | University of Birmingham | ||||
Date of Award: | 2007 | ||||
Availability of Full Text: |
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Abstract: | |||||
The HLA-DQ molecule is an important determinant of the risk of type 1 diabetes. The level of expression of predisposing and protective DQ variants may contribute to their influence on disease risk. Chapter 2 shows that the alleles encoding these variants differ in their expression at the mRNA level; DQA1 *0301 and DQB1 *06 were overexpressed compared with other alleles, while DQB1 *02 transcripts were less abundant. These differences correlate with differences in the promoter activity of the alleles, reported in Chapter 3. There was no simple relationship between the level of I expression of an allele and its influence on disease risk. Chapter 4 describes the first study to report the prevalence of latent autoimmune diabetes in adults (LADA), a subtype of diabetes, in the UK-resident South Asian , population. This disease is uncommon in the Punjabi population of Birmingham, but islet autoimmunity is associated with a similar clinical and HLA genetic profile to that seen in other ethnic groups.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.487514 | DOI: | Not available | ||
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