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Title: Effect of ethnicity and breast cancer treatment on menopausal symptoms. Expressio~ ofCGRP in human adipbse tissue in relation to menopausal status
Author: Pratima, Gupta
ISNI:       0000 0001 3498 5619
Awarding Body: University of Birmingham
Current Institution: University of Birmingham
Date of Award: 2007
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This thesis comprises a series ofqklitative and quantitative studies investigating the effects of the menopause on women's health and quality oflife. The qualitative research showed the intra-ethnic differences in vasomotor symptoms, which were significantly influenced by the country of residence. The emotional and somatic symptoms were influenced by health, co-morbidity and previo~ depressive symptoms. The fmdings from the thesis highlighted that Asian women living in the UK had a higher prevalence of menopausal symptoms, independent of Western . acculturation and less understanding of the Western concept ofthe menopause. The quantitative assessments addressed the potential mechanisms of how vasomotor symptoms manifest at the molecular level and the role of increasing adiposity as a factor contributing to the severity of hot flushes. These studies showed altered expression of the vasoactive peptides, calcitonin gene related peptide and adrenomedullin, with menopausal status. The findings highlighted one of the potential mechanisms to explain the vasomotor symptoms, insulin resistance and increased cardiovascular disease risk associated with adiposity in postmenopausal state. The studies emphasise the difficulties in understanding the pathophysiology of the menopause at the molecular and clinical level; addressing these may ultimately improve the health and welfare ofwomen during and after menopausal transition.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available