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Title: Maternal versus paternal factors in the heritability of asthma
Author: Carroll, Will
ISNI:       0000 0001 3521 9975
Awarding Body: Keele University
Current Institution: Keele University
Date of Award: 2007
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Asthma is a complex disorder with environmental and genetic triggers. These have been the subject of extensive study but progress in establishing reliable genetic determinants of this disease have met with only limited success. In this thesis I report on how the asthma phenotype in childhood varies within different populations of asthmatic children and how this might influence the results of our studies and those of other authors. I then critically review each component of the asthma phenotype and discuss its usefulness as· a marker of the disease within the population studied. I then go on to determine genetic associations between individual and parental genotype and phenotypic expression within children using a structured candidate gene approach. Following this approach it is evident that parts of the asthma phenotype, specifically airway hyperresponsiveness as measured by methacholine challenge varies consid~rably between different regional asthma centres.The reasons for this variation are unknown but limit the usefulness of this measure as an endpoint within our cohort 'of children. Subsequent detailed examination of other potential markers of- the asthma phenotype include an asthma severity score based on international guidelines, lung function measurements, total serum immunoglobulin E levels and the results of skin prick tests.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available