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Title: Synthesis and coordination chemistry of scorpionate ligands and their applications in 11C-positron emission tomography
Author: Kealey, Steven
ISNI:       0000 0001 3595 9906
Awarding Body: Imperial College London
Current Institution: Imperial College London
Date of Award: 2008
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This thesis is concerned with the synthesis and coordination chemistry of· a range of poly(pyrazolyl)borate 'scorpionate' ligands and examines their suitability in facilitating rapid [llC]carbonylation reactions to form radiotracers for application in positron emission tomography (PET). Author (full names): Steven Kealey Title of thesis: Synthesis and Coordination Chemistry of Scorpionate Ligands and their Applications in He-Positron Emission Tomography The second part of this thesis concerns the use of a copper(I)-Tp system for selectively solubilising llCO from nitrogen-rich gas streams for subsequent use in palladium-catalysed carbonylation reactions between amines and aryl-halides to form amides. These reactions were performed on a microfluidic device and in Schlenk apparatus using unlabelled carbon monoxide. These reactions ~were transferred to the radiochemical laboratory whereby efficient llCO trapping was observed prior to the formation of llC-radiolabelled amides. The third part of this thesis explores the coordination chemistry of palladium(II) towards a novel hybrid ligand consisting of pyrazolyl and triphenylphosphine moieties. The potential hemilabile behaviour of this ligand and its derivatives towards palladium was investigated and the use of these complexes as catalysts for carbonylation reactions is described. The final part of this thesis examines the coordination chemistry of poly(pyrazolyl)borates bearing additional coordinating groups appended to the 3- or 5~position ofthe pyrazolyl rings. Reactions ofthe 3-substituted derivatives were carried out with a range of metals and found to display varied coordination behaviour depending on the specific coordination requirements ofthe metal.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available