The entorhinal cortex (EC) is a vital structure in the mammalian brain, implicated in the processes of learning and memory, and a possible site for the generation of seizures in temporal lobe epilepsy. Neurones in the EC are constantly bombarded with inhibitory and excitatory neurotransmitter. This background activity is thought to exert significant control on the excitability and function of neurones in cortical networks, with changes in the levels and proportion of background inhibition (IBg) and excitation (EBg) driving rhythmic oscillations in membrane potential, and even underlying the generation of epileptic seizures.