Title:
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Randomised controlled trial of a programme to reduce risk factors in patients waiting for coronary artery bypass surgery
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The thesis is a report of a randomised controlled trial with 188 patients to evaluate a nurseled
education and support programme in terms of outcomes, process and context.
The 'Fit For Surgery' programme was based on previous studies suggesting substantial
benefit in controlling anxiety and risk factors contributing to coronary disease while patients
wait for coronary artery bypass surgery.
Patients listed for coronary artery bypass surgery with at least one poorly controlled risk
factor were randomised to standard care or the intervention which provided lifestyle
management counselling, and physical and psychological preparation for surgery in monthly
visits to the patients' homes. The trial measured progress from baseline to 3 months after
discharge. Primary outcome measurements were anxiety, blood pressure, cholesterol, body
mass index and length of stay. Secondary outcomes were quality of life (measured t>y the
HAD scale, SF-36 form and Coronary Artery Revascularisation Questionnaire) and
complications during admission. Costs of the intervention were calculated. Views of patients
and staff were collected by 'Discovery Interviews', a quality improvement tool devised by the
NHS Modernisation agency, and focus groups.
For both Intervention and Control groups blood pressure and total cholesterol improved
(Blood pressure (Control -9.11mmHg (CI -4.89, -13.33); Intervention -13.02mmHg (CI -8.76, 17.29)
both p<0.01); total cholesterol (Control -0.20mmoJlI (CI -0.03, -0.37) p=0.02,
Intervention -0.18mmolll (CI -0.02, -0.34) p=0.03). However there were no significant
differences between the groups in the primary outcome measures at any of the
measurement points. Qualitative data suggested the patients appreciated support from the
nurses but varied in their understanding of the programme and degree of motivation to
improve their health. Cost minimization analysis showed the total costs were less in the
intervention group due to less in-patient admissions during the waiting period (Total costs
��?���£9898 (3234) v 11427 (5400), CI-2813, -244; P= 0.02).
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