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Title: Psychological well-being in liver transplant patients.
Author: Millen, Sharon Elizabeth
ISNI:       0000 0001 3399 1101
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2007
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Liver transplantation is a widespread treatment for both acute and chronic liver disease. Previous research has indicated that psychological well-being is strongly associated with positive health outcomes post-transplant. There is also evidence however to suggest a significant level of psychiatric morbidity in patients posttransplant. Therefore, it is essential to evaluate liver transplant surgery according to both physical and psychological results. This study implemented a longitudinal mixed methods approach. The objectives were; to describe the experience of patients awaiting liver transplant surgery, to examine the relationships between psychological state pre-transplant and psychological health status post-transplant; to explore any changes made to an individual's frame of reference used for self-evaluation of Health-Related Quality of Life (HRQoL) and to identify any factors that were associated with this change. One-to-one interviews were conducted with 18 participants with end-stage liver disease (ESLD); 9 ofthese participants were interviewed again at 1 month, 3 months and 9 months post liver transplant. Thematic analysis produced 5 themes across time: impact of liver disease/transplant on patients' life, emotional reaction to liver disease/transplant, methods of coping with liver disease/transplant, support ofothers and perception ofthe future. Quantitative analyses indicated an improvement in HRQoL from pre-transplant to 3 months post-transplant. High levels ofanxiety were evident at I-month post surgery whist depression decreased over time. Optimism scores increased from pretransplant to post 9 months. Response shift effects were observed at all posttransplant time-points with patients rating their HRQoL significantly lower (on average) in retrospect than they did at pre-transplant. The largest response shift occurred at 3-months post-transplant. The occurrence of response shift in HRQoL ratings over time for1his population could have implications for the estimation of the effectiveness ofliver transplant surgery
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available