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Title: Processing and modification of injectable calcium phosphate systems for orthopaedic applications
Author: Jack, Valencera
ISNI:       0000 0001 3587 8452
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2007
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CPC are currently used in a range of applications however;. their low compressive strength and brittle failure mechanics have limited their widespread application. The aim ofthis study was to improve the mechanical performance ofCPC. The factors involved in the preparation of 0.-TCP were investigated and an optimal process was identified. Three milling techniques were explored and their process parameters optimised. The powders were subsequently reacted with water to form CDHA. Polymeric additives were incorporated into the cement. In vitro dissolution tests were set up to study cement behaviour in simulated physiological conditions. The cement and cement constituents were subjected to chemical, mechanical and microscopic analyses. It was determined that treatment temperatures of 1400°C with accelerated cooling produced pure 0.-TCP powders. All three milling techniques were shown to be efficient for particle reduction and the mechanical, setting and injectability properties were significantly improved by the reduction in particle size of the a.-TCP powder. The addition of PGA granules led to a decrease in the compressive strength and significant improvements in injectability and setting times of the cements. With a 1wt% addition of cryogenically ground PGA fibres CPC compressive strength increased by 60%. This level of addition was not found to compromise the setting time and had minimal effect on injectability. In vitro dissolution tests demonstrated increasing crystallinity and strength of calcium phosphate cement over 12 weeks. Polyglycolic acid additives were still observed in the cement after 12 weeks, however it was predicted that the granules would degrade to form a porous structure during a longer experimental period. Both CPC and CPCIPGA cement systems developed during this research have shown the potential for significantly improving the quality of life of patients suffering from bone disease and trauma.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available