Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486111 |
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Title: | Effects of lung tumour cells on the phenotype and function of human astrocytes and endolithial cells | ||||
Author: | Maskell, Lesley |
ISNI:
0000 0001 3620 6092
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Awarding Body: | University of Exeter | ||||
Current Institution: | University of Exeter | ||||
Date of Award: | 2008 | ||||
Availability of Full Text: |
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Abstract: | |||||
Brain metastases arlsmg from lung tumours are relatively common.
Metastasis formation involves events initiated by the tumour cell, including the
release of proteolytic enzymes, cytokines and growth factors, and also the
induction of angiogenesis Le. the formation of new blood vessels. Tumour cells
migrate through the endothelial cell layer lining cerebral blood vessels and contact
astrocytes (the main supporting cells of the brain). Characteristically a boundary
forms around the metastasis restricting further brain invasion. The cellular
processes involved in metastasis formation are largely unknown.Using an in vitro model this study investigated the cellular changes induced
(',
by human lung tumour cells on human astrocytes and endothelial cells. {\strocytic
changes during direct cell:cell contact with lung tumour cells were examined as a
model of boundary formation and a novel in vitro tubule formation assay was
developed to examine the angiogenic potential of human lung tumour cells.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.486111 | DOI: | Not available | ||
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