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Title: The role of the extracellular matrix in retinal vascular disease
Author: Coleman, Gary John
ISNI:       0000 0001 3560 2042
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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Originally believed to serve as a selective barrier and scaffold to which cells adhere, it has become evident that the individual components of the basement membrane (BM) are regulators of biological activities such as cell growth, differentiation, and migration, and that they influence tissue development and repair (Erickson and Couchman, 2000). Based on the emerging importance ofBM's in critical aspects of cellular activity, this thesis was undertaken in an attempt to further elucidate the role of these biologically-active regulatory proteins in the context of.retinal microvascular disease. The salient findings of this investigation were as follows; The a2(IV)NCl domain of typ~ IV human collagen inhibits angiogenesis in the retinal microvasculature in both in vitro (p
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available