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Title: Fatigue in gynaecological cancer : a prospective longitudinal survey
Author: Prue, Gillian Elizabeth
ISNI:       0000 0001 3502 4895
Awarding Body: University of Ulster
Current Institution: Ulster University
Date of Award: 2007
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Fatigue in gynaecological cancer has received minimal investigation. The aims of the longitudinal survey were therefore to analyse the fatigue experienced over 12 months by a gynaecological cancer population, to determine if the fatigue was more severe than that reported by non-cancer female volunteers, and to explore the variables associated with cancer-related fatigue (CRF). Methods: A feasibility study was carried out to ensure the chosen fatigue questionnaire was acceptable to individuals with gynaecological cancer and to test operational aspects of the main study. A 'multiple point prospective longitudinal survey was implemented involving gynaecological cancer patients from three cancer centres, and a group of age and gender matched controls with no cancer history. Data was collected at various predetermined intervals over a 12 month period post surgery (if indicated); before, during and after anti-cancer treatment. Fatigue was assessed using the MFSI-SF. Results: Sixty-five cancer patients (mean age 57.4, SD 13.9) and 60 non-cancer subjects (mean age 55.4, SD 13.6) participated. General Linear Modelling (GLM) indicated that females with cancer 'had significantly worse fatigue than females with no cancer history at all time points (p = 0.00). The level of CRF changed with time (p = 0.02). A forward stepwise regression demonstrated that psychological distress level, as measured by the Rotterdam Symptom Checklist (RSCL), was the only independent predictor of CRF during, anti-cancer treatment (p = 0.00). After treatment, both psychological distress level (p = 0.00) and physical symptom distress (p = 0.03) as measured by the RSCL were independent predictors of fatigue. Conclusions: Individuals with gynaecological cancer experienced significantly worse fatigue than non-cancer females during and after anti-cancer treatment. Psychological distress was found to be an important indicator of.CRF in this population. These findings indicate a need for further research regarding the management ofCRF in women with gynaecological cancer.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available