Use this URL to cite or link to this record in EThOS:
Title: Corpus callosum morphology in health and disease
Author: Wignall, Emma Louise
ISNI:       0000 0001 3567 9998
Awarding Body: University of Sheffield
Current Institution: University of Sheffield
Date of Award: 2006
Availability of Full Text:
Access from EThOS:
The corpus callosum has a distinct topographical organisation along its length, with different cortical areas connecting through different regions of the callosum. This has led to a number of different ways to divide the callosum along its length. The aim of this thesis was to apply a relatively novel method of callosal sub~ivision to look for meaningful brain/behaviour correlations in bimanual coordination and dichotic listening tasks. Measurements of the corpus callosum were obtained from a cohort of healthy adults who underwent magnetic resonance (MR) imaging. The same method was also applied to examine differences in callosal size in adults with Neurofibromatosis type I (NFl), a disease in which a larger callosum has been found in children with NFL In addition, diffusion tensor imaging was also obtained to examine underlying microstructural differences in regions of size difference. Chapter one provides an overview of normal callosal development, topographical arrangement and differences in fibre composition across the length and a discussion of methods of callosal subdivision. Finally, a basic MR physics section and more specifically diffusion tensor imaging is provided. Chapter two is a generic methods section discussing how the callosal measures used to produce brain/behaviour correlations in the subsequent two chapters were obtained. Chapters three and four discuss the brain/behaviour relationships derived from the bimanual coordination (chapter three) and dichotic listening (chapter four) tasks. Chapter five is the examination of callosal size in adults with NFl and mat~hed healthy controls and subsequent diffusion tensor imaging investigation. Finally, chapter six reviews the results of the brain/behaviour correlations, their place in the literature and possible future investigations. The results of chapter five are also discussed with possible future investigations of brain/behaviour relationships. Finally, future methods of callosal divisions based on better understanding of the underlying cortical connections are theorised.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available