Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485058 |
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Title: | Clean green chemistry : enzyme-catalysed and chemical asymetric synthesis | ||||
Author: | McGregor, Stuart Thomas |
ISNI:
0000 0001 3624 5489
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Awarding Body: | Queen's University Belfast | ||||
Current Institution: | Queen's University Belfast | ||||
Date of Award: | 2008 | ||||
Availability of Full Text: |
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Abstract: | |||||
Chapter 1 provides an introduction to the metabolism of aromatic compounds by
enzymes, and the use of bioproducts in synthesis. A brief introduction into the synthesis
and potential applications of amino alcohols is also discussed. Finally, a summary of a
number of methods for the-determination of enantiomeric excess concludes the chapter.
Chapter 2 investigates the synthesis oftrans-dihydrodiols from their cis-dihydrodiol
precursors. The desymmetrisation ofmeso-l,2-dihydroxycyclohexane is also discussed.
The chemoenzymatic synthesis oftrans-I,2-aminocyclohexanols, including the
biologically important compound vesamicol is examined. Chapter 3 explores the
synthesis of a number ofcis- and trans-azido alcohols from bromo- and chIoro- benzene,
and the conversion ofthe azido alcohols to cis- and trans-amino alcohols. A brief
investigation into the substitution ofthe halide atom in bromobenzene-cis-diol is
discussed as a potential route to a library ofcis- and (rmlS- amino alcohols. Chapter 4 is
divided into three parts. The first section discusses a number of synthetic routes to vicinal
cis- and trmls- amino alcohol derivatives of naphthalene. The second section outlines the
bacterial metabolism ofselected polycyclic aromatic hydrocarbons and the formation of
bis-cis-diols. The final section introduces a new class of bacterial metabolites from
acetonide-protected diol substrates.
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Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.485058 | DOI: | Not available | ||
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