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Title: Is there an association between systemic lupus erythematosus and cervical smear abnormalities? : a Northern Ireland survey
Author: McHenry, Michelle Therese
ISNI:       0000 0001 3624 6860
Awarding Body: Queen's University Belfast
Current Institution: Queen's University Belfast
Date of Award: 2008
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SLE is a multisystem autoimmune disease with the, primary problem as a malfunctioning immune system. As a result of the self-destruction and damage the disease process may require immunosuppressive therapy. Immunosuppressive therapy has been associated with an increased malignancy potential. Lupus and its treatment maY' therefore increase a patient's susceptibility to cell damage and infection. A long-standing concern in managing lupus patients has been the potential of development of abnormal cervical smear results and the associated predisposing factors. This research encompasses two study groups to assess this concern and potential risk. Study 1. A retrospective study assessing SLE patient's occurrence of an abnormal Papanicolaou test compared to anonymous matched controls. In addition, the role of SLE and associated disease related factors are assessed. Study 2. Is a real time case control study of a subgroup of SLE patients from Study 1. The role of traditional cervical cancer risk factors and HPV detection as well as SLE itself on the development of an abnormal cervical smear in SLE was assessed. .Results from Study 1 confirm an increased reporting of abnormal cervical smears in SLE patients. This includes an i,ncrease in the number of abnormal cervical smears, the occurrence of high-grade abnormalities and reporting of Koilocytosis. Results from Study 2 confirmed the increased occurrence of an abnormal cervical smear history in SLE despite adjusting for traditional cervical cancer risk factors. Disease activity was statistically different in those with an abnormal cervical smear history after the diagnosis of SLE. Though there was no difference in the frequency of detection of HPV between SLE and controls there was a significant difference in the age at detection of HPV. The SLE patients who were HPV positive being older than HPV positive controls.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available