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Title: Characterisation of the Expression and Function of XtSulf-1 during Xenopus Development
Author: Freeman, Stephen D.
ISNI:       0000 0001 3483 9531
Awarding Body: The University of York
Current Institution: University of York
Date of Award: 2007
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Heparan sulphate proteoglycans (HSPGs) are cell surface molecules that act as co- . receptors for a number of important signalling ligands such as the fibroblast growth factors (FGFs). The Sulf-l enzyme was recently identified by Dhoot et aL, (2001) as a modifier of HSPG structure. Specifically, Sulf-l removes sulphate groups from the 6-0 position of the glycosaminoglycan chains which decorate the HSPG core. In doing so, Sulf-l affects the ability of HSPGs to bind to both signalling ligands and receptors. Previous studies have shown that Sulf-l can inhibit F'GF signalling (Wang et aI., 2004). This thesis advances previous work by providing a complete expression analysis of the Su/f-l gene in the early Xenopus tropicalis embryo. It shows that XtSulf-l acts as an endogenous FGF inhibitor, and shows for the first time that it also acts as an endogenous BMP inhibitor. This work reveals that XtSu/f-1 .is an essential regulator of cell signalling events in the early Xenopus embryo.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available