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Title: Development of selective non-metal based organocatalysts for asymmetric synthesis
Author: Carley, Allison Patricia
ISNI:       0000 0001 3520 1126
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2007
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This thesis is concerned with the design, synthesis and use of novel bifunctional organocatalysts for the asymmetric Michael addition of ketones and 1, 3 - dicarbonyl compounds to trans - ~ - nitrostyrene. Chapter 1 describes the concept of organocatalysis, including history and mode of action. A detailed review is provided on the organocatalytic Michael addition of carbon nucleophik~s to nitroolefins. The bifunctional organocatalyst design and programme ofwork is also discussed. Chapter 2 details initial investigations conducted on the organocatalytic Michael addition of cyclohexanone to trans - ~ - nitrostyrene using monofunctional amine catalysts and hydrogen bond donor catalysts. Chapters 3, 4 and 5 depict the synthesis and testing of a range of novel bifunctional organocatalysts for the rYfichael addition ofcyclohexanone to trans - ~ - nitrostyrene. Ch,:iptl~r 6 the different bifunctional organocatalysts and explores the scope rvIichael addition reaction.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available