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Title: Characteristics of oxalate supported calcium uptake and release from the SR of permeabilised rabbit ventricular myocytes
Author: Bruce, Lorraine
ISNI:       0000 0001 3506 0589
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2003
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This thesis investigated the characteristics of sarcoplasmic reticulum (SR) calcium uptake and release from permeabilised cardiac myocytes: focusing on adenosine trisphosphate calcium pump (Ca+2 -ATPase pump), the ryanodine receptor (RyR) and the non-specific SR leak. In order to do this, the following aims were investigated. 1. Cell viability: do balled-up cells contribute to total cell protein? 2. Is the rate of calcium uptake and leak affected by SR calcium load, RuR and by varying the oxalate concentration? 3. How sensitive is this preparation to stimulatory and inhibitory concentrations of ryanodine? 4. To what extent is the caffeine-mediated calcium leak blocked by ryanodine and ruthenium red (RuR)? 5. What are the characteristics of the RuR/ryanodine insensitive SR leak?
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available