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Title: The effects of anti-schistosome drugs on schistosomes and the immune responses of their hosts
Author: Sharaf, Osama Fathy
ISNI:       0000 0001 3397 212X
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 2004
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The effects of Mirazid® (MZD), an extract of myrrh, on Schistosoma mansoni were investigated and compared to those of praziquantel (PZQ). The effects of both drugs on the soluble proteome and the immune responses to schistosome infections were also investigated. In vitro studies showed that MZD was more effective than PZQ against the schistosomula stage. However, its effects against adult worms were less than those of PZQ. Lengthy exposures to high concentrations of MZD were required for the drug to be effective. In vivo studies showed that MZD had no anti-schistosomal activity against S. mansoni in mice. In vitro exposure of adult worms to either PZQ or MZD caused significant changes in the expression of some proteins. Interestingly, some vaccine candidates including paramyosin and actin were among the proteins that showed differential expression. Treatment of human S. haematobium infection with PZQ favoured the development of protective immune responses that render the individuals resistant to reinfection. Sera from putatively resistant individuals showed distinct recognition patterns of soluble worm antigen, after exposure to reinfection, compared to sera from susceptible individuals. Interestingly, many putative vaccine candidate antigens were recognised by antibody isotypes that are found in individuals with some degree of resistance to infection. In conclusion, although the in vitro studies revealed some promising effects of MZD, the results of the in vivo studies do not support the use of this drug in the treatment of schistosome infections.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: QR180 Immunology ; QL Zoology