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Title: Studies on the biosynthesis of bis-lactone antibiotics
Author: Johnston, Grant Alexander
ISNI:       0000 0001 3591 5460
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1979
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In this research it has been shown by incorporation experiments using synthetic, labelled precursors that the antibiotics ethisolide (1) and canadensolide (2) have closely related biosynthetic origins in the appropriately substituted citric acids derived from condensation of a fatty acid derived moiety with a TCA cycle acid (probably oxaloacetate). The most convincing evidence to date for this pathway comes from the efficient and specific incorporation by P. canaderse of alpha-n-hexylitaconic acid into canadensolide (2) and the related metabolites.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry