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Title: Some chemical and pharmacological aspects of copper and gold.
Author: Iqbal, M. S.
Awarding Body: University of Strathclyde
Current Institution: University of Strathclyde
Date of Award: 1982
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The work presented in this thesis concerns the role of copper and gold in rheumatoid arthritis. The anti-inflammatory (AI) activity of copper complexes has received much attention since the claim that complexes of AI drugs with copper are more active than the AI drug itself. In the present study copper Schiff base complexes have been included. The Schiff bases were derived from naturally occurring amino acids. The complexes prepared were characterized by microanalysis, IR, UV-vis, circular dichroism, magnetic moments, differential scanning calorimetry, and ekectron spin resonance. An elongated tetragonal copper (II) ion environment with a dx2-y2 ground state has been suggested for these complexes. Some of the copper complexes were found to be binuclear with the two copper atoms associated through bridging groups. The Cu-Cu separation, calculated from the triplet-state ESR spectra, was found to be 3.82-4.25 A in such cases. Some of the complexes were found active in kaolin-induced rat paw oedema test after oral administration while all of them showed antiulcer activity. Stable gold (III) complexes with Schiff bases, particularly containing l-cysteine and bis(3-aminopropyl) phenyl phosphine as part of the base, are also reported in this work and their importance with respect to gold (III) toxicity is discussed. In vitro redox reactions as models for in vivo reactivity of gold were studied and it was found that these reactions are affected by the nature of the solvent. Triethylphosphine gold chloride, an orally administered drug, was allowed to react with l-cysteine and the reaction was studied by circular dichroism and HNMR. About four different species were detected in solution over a period of two weeks. In clinical trials of auranofin, a newly introduced drug, the distribution of gold in blood was determined using electro-thermal atomisation. The correlation of drug efficacy and toxicity with whole blood, plasma haemolysate and cell membrane gold is discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Biochemistry