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Title: An introductory epidemiological and immunological study of arthritis in sheep of slaughter age
Author: Lamont, M. H.
ISNI:       0000 0001 3604 4820
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1978
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The work began with an abattoir survey whose aim was to identify the major causes of loss due to arthritis. Erysipelothrix rhusiopathiae was the most common bacterial infection, and the remainder of the work concerns this organism and its disease in sheep. The first review of' the literature deals with the natural history of the organism, particularly in relation to its infection in sheep. The remainder of Section I deals with ovine serotypes of E.rhusiopathiae, interpretation of antibody titres and evidence that subclinical infection with E.rhusiopathiae can occur. Finally, attention is drawn to the susceptibility of the bacteria to diluents containing insufficient organic matter. Section IT describes the experimental work carried out which investigated the use of E.rhusiopathiae vaccine and antiserum in sheep. The literature pertaining to the use of inactivated i vaccines is reviewed. An experiment was carried out which failed to demonstrate that that lambs could be protected against polyarthritis by the prophylactic use of antiserum or maternal vaccination. ' In subsequent experiments some of the possible reasons for this apparent failure were studied. It was found that the criteria which had been adopted as indicators of immunity, that is, rise in antibody titre and resistance to intravenous challenge, were unsuitable, but that active and passive immunity against E.rhusiopathiae could be shown when animals were challenged by intradermal injection of live organisms. Finally, the findings of the whole work are discussed with particular reference to the epidemiology of E.rhusiopathiae infection in sheep, and various hypotheses are put forward which explain the observed phenomenon. The osteo-arthritic condition found most often was a bilateral cubital osteo-arthritis seen in older sheep. Some of these jqints were examined in more detail and a hypothesis put forward to explain the development of the lesions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Sheep arthritedes