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Title: Synthetic approaches to nuclearly-modified cephalosporin antibiotics
Author: Bremner, John Alexander Smith
ISNI:       0000 0001 3478 4753
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1977
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Synthetic routes to a 1-hydroxy-1-carbacephem (1), by structure-activity considerations an analogue of potential antibiotic activity, are described. Synthesis of a substituted pyridine for reduction to a cyclic enamine and subsequent annellation to a B-lactam were not successful. An acyclic inline precursor of (1) was prepared but did not yield a beta-lactam by an established annellation procedure. Approaches to a cyclic amine potentially convertible into (1) are described.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available