Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.479448 |
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Title: | Radical synthesis of quinazolinone natural products | ||||||
Author: | Stein, Tobias |
ISNI:
0000 0001 3479 7749
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Awarding Body: | Loughborough University | ||||||
Current Institution: | Loughborough University | ||||||
Date of Award: | 2007 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Investigations into radical and palladium(0) cyclisations onto the C-2 position of the 3H-quinazolin-4-one moiety have been made. This has led to the syntheses of a number of biologically active quinazolinone natural products using alkyl, heteroaryl and acyl radical cyclisations. The reactions proceeded via a homolytic aromatic substitution mechanism. As such, fully rearomatised products were recovered. A C-2 radical 3H-quinazolin-4-one building block was also prepared. This turned out to have only limited synthetic applications. Radical cyclisations onto aryl groups were carried out using this building block.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.479448 | DOI: | Not available | ||||
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