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Title: Blood oxygen level dependent (BOLD) MRI in the diagnosis of myocardial ischaemia
Author: Egred, Mohaned
ISNI:       0000 0001 3442 0220
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2006
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The purpose of this project was to assess the use of a new MRI technique, Blood Oxygen Level Dependent (BOLD) in the diagnosis and assessment of coronary artery disease. BOLD was firstly compared to coronary artery angiography, which is considered to be the gold standard for the diagnosis of coronary artery disease, in a group of patients with 3-vessel coronary artery disease.  The results were encouraging, as the detection rate of the ischemic areas by BOLD MRI was 81% based on the signal change between rest and stress. Subsequently, the signal change on MRI BOLD was assessed, in patients with 3-vessel disease and reversible ischemia on PET, in the ischemic myocardial areas identified on PET and compared to the non-ischemic areas.  The signal change in the ischemic areas was significantly different from that in the areas identified as having no reversible ischemia.  Wall motion thickening was also assessed using cine-MRI method and this again was significantly different between ischemic and non-ischemic myocardium.  The combination of both BOLD signal change and wall thickening can possibly identify myocardium with stress induced reversible ischemia. The BOLD technique was also evaluated in a similar group of patients to the previous one and compared in ischemic and non-ischemic areas as identified on SPECT images.  The signal change on BOLD MRI showed a strong trend towards significance and wall thickening was significantly different between the ischemic and non-ischemic myocardium and indicate again that BOLD MRI may be used to identify ischemic myocardium. Furthermore, signal change on BOLD was again investigated and assessed in hibernating and scarred myocardium.  BOLD MRI can possibly identify hibernating myocardium and help in devising a management plan in this group of patients.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available