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Title: Apoptosis in the rat adrenal cortex
Author: Wyllie, A. H.
ISNI:       0000 0001 3573 5857
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1975
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The morphology of psychological cell death in the adrenal cortex is described for the first time. Dying cells undergo a characteristic sequence of changes, notably nuclear disintegration and cytoplasmic condensation, with preservation of the structural integrity of organelles. The condensed cells split into fragments which then undergo phagocytosis within histiocytes. The entire process is completed within 24 hours. This mode of death is morphologically identical with that described in normal embryonic development, metamorphosis and atrophy. To emphasise its widespread occurrence and possible significance in living tissue it has been termed apoptosis. In the normal adult rat adrenal cortex approximately the game number of cella undergo apoptosis as mitosis. ACTH withdrawal, occurring physiologically in the neonate or induced experimentally in the foetus and adult, greatly enhances adrenocortical apoptosis within a few hours. Susceptibility to apoptosis on ACTH withdrawal is limited to cells of the zona reticularis. Prolonged intense ACTH stimulation renders even these cells temporarily insusceptible. These findings support the hypothesis that apoptosis may be an intrinsically programmed, potentially controllable phenomenon of significance in tissue homeostasis in the adrenal cortex* The more general relevance of apoptosis is also discussed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available