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Title: Studies on acute hyperbaric pulmonary oxygen toxicity
Author: Shields, Thomas Gillies
ISNI:       0000 0001 3405 9156
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1976
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A pathophysiological study was made of spontaneously breathing dogs anaesthetised by a neurolept-analgesic technique and exposed to 100% oxygen at 2 ATA to demonstrate the time-course and mechanism of response. The animals remained apparently normal for some 18 hours, following which the majority developed a fulminating intra-alveolar oedema and died of hypoxaemia within a few hours. There was no evidence of systemic nor pulmonary capillary hypertension, and electron microscopy demonstrated complete absence of damage to the endothelial and Type 1 epithelial cells of the alveolar septum. Changes were detected in the Type 2 cells, and oedemagenesis was attributed to an oxygen-induced depression of surfactant activity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: RM Therapeutics. Pharmacology