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Title: Quantitative single photon emission computerized transaxial tomography
Author: Rowe, R. W.
Awarding Body: Aberdeen University
Current Institution: University of Aberdeen
Date of Award: 1979
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Single photon emission transverse section tomography maps the activity concentration of selected radioactive tracers in a thin slice of an object. In the human body this allows the monitoring of specific physiological functions and has considerable, but hitherto unrealized, quantitative potential. The mathematical foundations of the techniques which permit quantitative measurement are presented and the requirements of the theory established together with their implications for practical systems. In practice not all the requirements can be met so the deviations from the theory and their effect on quantitivity are discussed. The two most serious problems, collimation and attenuation, are considered in more detail. In particular, the design of a new collimator combination for the Aberdeen Section Scanner is presented together with experimental results showing the improved depth independence of response and resultant increase in quantitative accuracy achieved. Methods of compensation for attenuation are reviewed and their effectiveness discussed. The iterative convolution procedure was selected to be most promising for implementation on systems without large computer resources and the high degree of accuracy achieved with this technique is demonstrated on a wide range of source distributions. An investigation of the use of statistical cluster analysis on tomographic images was carried out. The results of application of a conditioned ratio method for analysing spatial patterns to liver tomograms are presented, showing the excellent potential of the technique for improving the diagnostic accuracy of the final images. Its use is recommended for extracting extra information from difficult tomograms where visual inspection alone cannot give satisfactory differential diagnosis.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available