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Title: The structure of the circulating lipoproteins of fish in relation to the transport of lipid and the deposition of egg yolk lipoproteins
Author: Rogie, Anne
ISNI:       0000 0001 3533 8173
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1978
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Very low density lipoproteins (VLDL), low density lipoproteins (LDL) and high, density lipoproteins (HDL) were isolated from the serum of the rainbow trout (Salmo gairdneri Richardson). The HDL was the predominant fraction. Chylomicrons were also shown to be present in the VLDL fraction. The VLDL and HDL showed similar flotation characteristics to the VLDL and HDL of human but the trout LDL was of higher density than the LDL of human. The lipid composition of the trout lipoprotein fractions was shown to bear some similarities to that of human lipoproteins. A high proportion of long chain polyunsaturated fatty acids was found in each class. No immunological interrelationship was found between LDL and HDL, but VLDL contained antigenic determinants in common with both. The amino acid composition of apo LDL was similar to that of apo B of other species, while the principal apoproteins of HDL showed characteristics similar to those of human apo A-I and apo A-II. Egg lipoproteins were isolated from the serum of cod (Gadus morhua L) and trout by. precipitation with dextran.sulphate and manganous chloride. The overall lipid and protein composition of the egg lipoproteins isolated from the serum was identical to that of egg lipoproteins isolated from eggs. Both had similar subunit composition. No precursor-product relationship between the serum and egg components, similar to that of avian and amphibian species, was identified. Immunological studies have shown that the egg lipoproteins and normal serum lipoproteins of trout do not share any common apoproteins. Oestradiol treatment of the trout was shown to produce an increase in the serum VLDL and LDL concentrations in addition to the egg lipoprotein concentration. These observations suggest that a similar lipid transport mechanism to that of higher vertebrates including man is in operation in the trout.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available