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Title: Observations on immune responses of sheep to Orf virus
Author: Maeda, Amy Denise
ISNI:       0000 0001 3616 2480
Awarding Body: University of Edinburgh
Current Institution: University of Edinburgh
Date of Award: 1980
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Sheep infected and re-infected with orf virus responded with lesions which evolved through classical pox stages of papule, vesicle, pustule and scab. In susceptible sheep they resolved within five weeks whereas in re-infected sheep there was an accelerated response, the lesions healing within three weeks. Experiments were designed to correlate the roles of humoral and cell-mediated immune responses with clinical responses. Sera were analysed for changes in the levels of total proteins, serum fractions, IgM, IgGl, IgG2 and antibodies. Leucuocytes from infected and re-infected sheep were also assayed for cell-mediated immune responses. Changes in the total serum proteins of infected and re-infected sheep, pre-challenge and post-challenge were not significant. Contrarily, there were significant in¬ creases in the gammaglobulin levels in re-infected sheep and slight increases in the levels in infected susceptible sheep. IgM levels of infected and re-infected sheep were not markedly altered. IgGl and IgG2, in contrast, increased significantly after infection and re-infection. The in¬ creases correlated positively with orf antibody titres. The rate of antibody production was significantly slower in infected sheep than in re-infected sheep and the titres attained were much lower in susceptible sheep than in re-infected sheep.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available