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Title: Studies of aromatic hydroxylation
Author: Gretton, William R.
ISNI:       0000 0001 3518 9630
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1973
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The conversion of [4-3H]- and [4-3H; 3,5-2H2]-phenyl-alanine into tyrosine by cultures of Pseudomonas sp. (NCIB 9289) has been studied. Fromm a consideration of the degree of retention of tritium observed during the hydroxylation of the two precursors a kinetic isotope effect, kD/kT = 2.8 ± 0.1 (kH/kD = 10 ± 1), has been calculated for the final aromatisation process following the NIH shift. The relevance of this result to the overall reaction pathway is discussed in the light of similar data derived from possible chemical models for the biological process.
Supervisor: Not available Sponsor: Science Research Council
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available