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Title: Synthetic routes to 14-aminocodeinone derivatives
Author: Gourlay, Ross Ian
ISNI:       0000 0001 3507 8076
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1979
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The synthesis of 14beta-acylaminocodeinones has been achieved via the Diels-Alder addition of nitrosocarbonyl-compounds to the activated diene system of the baine. Several variations on this route have been investigated and the most efficient yields the desired products in greater than 60% yield from the baine. The analgesic properties and structure/activity relationships of several of these compounds and their precursors with differing alkyl and aryl side chains have been established.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available