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Title: Proton NMR relaxation time measurements in some biological tissues
Author: Gordon, Robert Emslie
ISNI:       0000 0001 3506 5179
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 1975
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In order to investigate the clinical potential of NMR relaxation time measurements in the detection and diagnosis of malignancy in excised tissue specimens, a pulse spectrometer (2MHs operating frequency, 1Kw pulse power) has been constructed for measuring T1 and T2 relaxation times of protons in biological tissues. The pulse sequences used are (TT-t -TT/2) for T1 and CPMG for T2. The spectrometer is equipped with a dual phase sensitive detector giving in-phase and quadrature phase outputs. Field stability is maintained by a flux stabiliser and a field correction unit operating on the quadrature signal following an FID. In the majority of cases T1 relaxation has been characterised by single exponential behaviour, (exceptions have been some human normal and tumour specimens and fat tissue) and in general the tumour specimens exhibit the greater relaxation times. Different examples of the same tissue type exhibit a range of values outwith that of experimental error which limits the extant to which the technique can be used to identify individual specimens. The only criterion for tissue identification established has been that no T1 of the normal tissues examined exceeds 650 msec. Whereas some tumour tissues do and the results indicate that this technique has only limited application in the detection and diagnosis of cancer. Two mechanisms which might account for the elevated T1 values have been investigated and the results obtained from water content estimation of normal and rat tissues show a definite correlation between water content and T1 which has been corroborated at a cellular level by immersion refractometric measurements of the cytoplasm in rat liver and hepatoma cells.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available