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Title: Induced abnormal bone growth with particular reference to the growth plate
Author: Duff, Stuart Roderick Iain
ISNI:       0000 0001 3433 9748
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1979
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Limb deformities were successfully produced in skeletally immature lambs following contralateral limb hip excision arthroplasty. In order to determine the growth potential of the ovine skeleton prior to induced pelvic limb imbalance a preliminary study of normal epiphyseal fusion in comparable lambs has been performed. A detailed investigation of the angular bone deformities that were produced was then Undertaken. In particular, the growth cartilage of deformed bones was studied and both decalcified and undecalcified sections of bone extremities prepared. Undscalcified sections permitted microradiographs to be produced and as sequential bone labels were administered the effect on longitudinal bone growth of limb imbalance could be assessed. In addition, angiography was performed and differences were visualised in the blood supply adjacent to the growth plate following induced limb imbalance. Although pronounced angular deformities were produced, in addition, a dramatic increase in bone torsion was encountered in tibiae. In metatarsi there was normally minimal or no torsion in control animals but those undergoing deformity exhibited marked axial rotation. By means of static load bearing and gait analysis observations, the aetiology of induced bone deformities has been investigated. It is postulated that asymmetrical growth plate loading occurs and, as a result, abnormal endochondral bone growth is produced.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Limb deformities in lambs