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Title: The chemistry of some dihydropyridines and the synthesis of ellipticine derivatives
Author: Driver, Michael
ISNI:       0000 0004 2667 7175
Awarding Body: University of Bath
Current Institution: University of Bath
Date of Award: 1979
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A brief summary of the anti-cancer activity of the ellipticines is made together with an indication of the geographical distribution of plants containing ellipticine and related alkaloids. A comprehensive review of the reported synthetic routes to ellipticine and its derivatives is included. During the course of investigations of one route to the tetracyclic system several new dihydropyridines have been isolated and identified. Modification of this route has led to the preparation of several, previously unreported, ellipticine derivatives while the examination of a new synthetic route has led to the preparation of 5-ethylellipticine. Attempts have been made to adapt this procedure to the preparation of other derivatives.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available