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Title: An investigation into selenium metabolism with reference to the interactions between vitamin E, selenium and other trace elements
Author: Coker, O. E.
ISNI:       0000 0001 3559 9592
Awarding Body: University of London
Current Institution: King's College London (University of London)
Date of Award: 1978
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Selenium has been shown to be essential for several animal species and, although essentiality has not been proven for Man, there are several lines of reasoning to suggest it. The recent discovery that selenium is an essential constituent of the enzyme glutathione peroxidase, which is found in the tissues of many animal species and has also been demonstrated in human erythrocytes, suggests that selenium may also be an essential element for Man. In addition, some of the urinary metabolites of selenium produced by man are the same as those produced by the rat, and the proven essentiality of selenium for the rat indicates that the same may be true for man. In the work described in this thesis, the effects of alterations in the dietary levels of selenium and vitamin E on the metabolic route for the detoxification of acute levels of selenium. have been examined in the rat. In addition, the activity of dietary conditions, and correlation between enzyme activity and the concentration of selenium in liver was studied. All experimental methods and enzymic assays have been described in detail. -. The effect of silver,. which causes selenium deficiency symptoms in vitamin E-deficient rats, onglutathione peroxidase activity and concentration of liver selenium was investigated. in an attempt to explain gross, physical manifestations by changes in parameters of selenium metabolism. In the presence of toxic levels of dietary selenium, the effect of silver on selenium detoxification was investigated. Finally, the short-term uptake of 75Se in various tissues of rats given vitamin E, selenium and toxic metals such as mercury, cadmium and silver, was measured and compared with control rats in order to begin to explore the nature of these elements with selenium and vitamin E.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available