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Title: Studies on the structure and replication of canine distemper virus
Author: Armitage, Aileen Margaret Thomson
ISNI:       0000 0001 3427 4489
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1976
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The principal aim of the investigation was to gain detailed information on the structure and replication of canine distemper virus. The first part of the thesis was intended to provide information on the growth of the virus in tissue culture to that a method could be established for the production of the large quantities of virus required for structural and biochemical studies. The growth of the virus in secondary dog kidney cultures, primary alveolar macrophage cultures, a canine embryonic cell strain, and the G-H continuous dog kidney cell line was compared. Secondary dog kidney cultures were the most susceptible to the virus but the highest yields were obtained from the GPI cells. By comparing different methods of infecting and maintaining the cells, it was found that large quantities of virus could best be obtained by infecting GH cells in monolayer and collecting the medium two or three times per day, once a clearly recognisable cytopathic effect was present.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available