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Title: Synthesis of new codeinone and indolinocodeinone derivatives
Author: Allen, R. M.
ISNI:       0000 0001 3416 7640
Awarding Body: Loughborough University of Technology
Current Institution: Loughborough University
Date of Award: 1971
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Derivatives of both 14-hydroxycodeinone and the Diels-Alder adducts of thebaine provide some of the most potent analgesics in the morphine–thebaine group of alkaloids. As an extension to the range of available compounds the preparation of modified thebaines and 14-N-substituted codeinones was a desirable objective. The synthesis of 7-alkyl- or aryl thebaines from salutaridine via the corresponding salutaridinols was attempted but the acid-catalysed cyclisation of the latter was not successful.
Supervisor: Not available Sponsor: Reckitt and Colman Ltd
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available