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Title: Stretch activation in muscle : a Ca²⁺ independent mechanism?
Author: De Nicola, Gian Felice
ISNI:       0000 0001 3420 4763
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2008
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The aim of this thesis has been the understanding at the molecular level of stretch activation in muscles. Stretch activation is a feature common to all types of muscle. Such a mechanism is particularly important in cardiac muscles in vertebrates and in indirect flight muscles in insects. Here, the three-dimensional structure of Lethocerus troponin C isoform (F1), recently discovered to be crucial in regulating stretch-activated contraction, is presented. The interactions between F1 and the other subunits of the Lethocerus troponin trimer are also analyzed. Finally a model for stretch activation in muscle, based on the experimental data produced during this thesis, is proposed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral