Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.446294 |
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Title: | Stretch activation in muscle : a Ca²⁺ independent mechanism? | ||||||
Author: | De Nicola, Gian Felice |
ISNI:
0000 0001 3420 4763
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Awarding Body: | Open University | ||||||
Current Institution: | Open University | ||||||
Date of Award: | 2008 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
The aim of this thesis has been the understanding at the molecular level of stretch activation in muscles. Stretch activation is a feature common to all types of muscle. Such a mechanism is particularly important in cardiac muscles in vertebrates and in indirect flight muscles in insects. Here, the three-dimensional structure of Lethocerus troponin C isoform (F1), recently discovered to be crucial in regulating stretch-activated contraction, is presented. The interactions between F1 and the other subunits of the Lethocerus troponin trimer are also analyzed. Finally a model for stretch activation in muscle, based on the experimental data produced during this thesis, is proposed.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.446294 | DOI: | |||||
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