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Title: Investigation of the influence of parathyroid hormone on bone metabolism in human subjects
Author: Black, Alison J.
ISNI:       0000 0001 2417 7474
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2006
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The aim of my thesis was to investigate the influence of PTH on bone metabolism in women at the menopause and in pregnancy. Firstly I examined the influence of PTH in early postmenopausal women. My results show that different PTH concentrations have significant effects on bone turnover but these are small in comparison to those of oestrogen. A clear seasonality was seen for PTH. The other major finding was that the highest quartile of Amino Terminal Propeptide of Type 1 Collagen (PINP) concentration predicted future fracture. Next I investigated the increased fracture risk in pregnancy.  Parathyroid Hormone Related Peptide (PTHrP) is important in calcium transfer for mother to fetus and I hypothesised that PTH/PTH fragments may have a role in bone changes in pregnancy. It is possible that low bone mass or high bone turnover may also be important. No major changes were seen in PTH concentrations during normal pregnancy; however bone resorption increased throughout pregnancy. Bone formation increased at a later stage. Detailed study of a woman with pre-existing Juvenile Idiopathic Osteoporosis (JIO) gave further insight into PTH influences in pregnancy.  Here baseline bone resorption was elevated and increased further in pregnancy. PTH fragment assays showed increases similar to those seen with bone formation. In conclusion, my studies have shown small but significant influences of PTH in the early postmenopausal years and highlighted the potential role of PINP in fracture prediction. PTH does not have major effects in normal pregnancy; however PTH fragments may have an important role in those with an exaggerated physiological response to pregnancy.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (M.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available