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Title: Regulation of glycosylation and cell wall biosynthesis in Candida albicans
Author: Collins, Claire L.
ISNI:       0000 0001 3560 5729
Awarding Body: University of Aberdeen
Current Institution: University of Aberdeen
Date of Award: 2006
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Manganese is an essential micronutrient for fungal growth---fungi deficient in manganese produce less cell wall. Using a LacZ promoter-reporter system and detailed microarray analyses manganese ions were shown to positively regulate transcription of many genes involved in O- and N-glycosylation and cell wall biosynthesis. The PKC and Ca 2+/calcineurin signalling pathways were shown to be involved in the regulation of these genes in response to manganese ions. Microarray analysis showed that in the longer term cells respond to high exogenous manganese ions by up-regulating the expression of multiple genes encoding cell wall proteins and genes concerned with glycosylation, chitin and lipid biosynthesis. At high concentrations manganese is also toxic to Candida albicans. However, the effects of manganese ions can be alleviated by magnesium ions suggesting they compete for transport and/or for activation of manganese-regulated processes. Therefore glycosylation of the cell wall in C. albicans and the expression of glycosylation and cell wall biosynthesis genes are regulated by manganese ions.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available