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Title: 3D quantitative elemental mapping of biological tissues using proton induced X-ray emission tomography (PIXE-T) and on/off-axis scanning transmission ion microscopy tomography (STIM-T)
Author: Beasley, Daniel
ISNI:       0000 0001 3452 6025
Awarding Body: University of Surrey
Current Institution: University of Surrey
Date of Award: 2006
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A novel experimental set-up was installed at the University of Surrey Ion Beam Centre for the purpose of producing 3D quantitative elemental maps of biological samples by combining simultaneous Proton Induced X-Ray Emission Tomography (PIXE- T), on/off-Axis Scanning Transmission Ion Microscopy-Tomography (STIM-T) and Rutherford Backscatter Spectrometry (RBS). A tomographic sample holder was designed and built and a scattering system developed for On/Off-Axis STIM. 2D PIXE and off-STIM analysis of leukocytes was performed to complement concurrent research and to identify problems with the very recently installed proton microbeam at the Ion Beam Centre. The other major aim was to see if a leukocyte would be a suitable sample for tomographic analysis and to study the damage induced by the beam on biological samples. Instrumental Neutron Activation Analysis (INAA) was performed on hair samples collected from MSc students at the University of Surrey and a database compiled of all elemental analysis of hair performed at the University. This complemented the tomographic analysis performed on a section of a strand of hair. Si, S, Cl, K, Ca, Fe and Zn were mapped using simultaneous PIXE-T, On/Off- Axis STIM-T and RBS.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available