The thesis outlines a hierarchical modelling methodology for investigation in vehicle dynamics, in particular for combined ride and handling manoeuvres. The methodology involves the use of detailed multi-degrees of freedom models of vehicles with the inclusion of sources of non-linearity, using a multi-body approach, based on Lagrangian dynamics for constrained systems. It also includes the use of simpler and task-specific models, formulated in Newton-Euler approach. These simpler models with lower degrees of freedom, but with appropriate level of detail are more efficient in the study of specific, but non-trivial problems such as transient behaviour of vehicles in combined ride and handling, as encountered in many routine daily manoeuvres. The modelling methodology is supported by careful vehicle testing, both for validation of the proposed approach, and assessment of the extent of applicability of simple, intermediate and multi-degrees of freedom full-vehicle models. Certain important vehicle handling and ride characteristics in pitch plane dynamics, roll behaviour, vehicle body bounce and combination of these have been studied, as well as the effectiveness of restraining action of chassis elements, such as the semileading and trailing arms for passive control of vehicle squat and dive motions, arising from acceleration from coast to drive and deceleration/brake of vehicle from drive to coast. Combined pitch and bounce motions have been studied when negotiating speed traps such as bumps, which also combine with significant body roll when single event obstacles of this kind are introduced. The novelty of the research is in the detailed integrative numerical-experimental approach, and the development of intermediate models that adequately predict vehicle behaviour under steady and non-steady conditions for a wide range of ride and handling manoeuvres. The investigations have culminated in a significant number of findings of practical use, particularly the ineffectiveness of anti-squat and dive features when combined pitch and bounce motions limit the usefulness of these devices. On the contrary, excessive roll dynamic behaviour of the vehicle is effectively palliated by the anti-roll bar, even under complex combined pitch, roll and body bounce such as those experienced in negotiating single event speed bumps. Good agreement is found between the predictions of the intermediate model and those of the multi-body model and the actual vehicle tests, particularly for pitch and bounce dynamics.