The isolated, perfused bovine eye model has a long proven track record as an established experimental model allowing the study of the physiology and pharmacology of aqueous humour. Wilson et al, 1993 have shown this model in numerous experiments to provide reproducible results, consistent with in vivo models. Shahidullah et al (1995, 1999) have since taken the use of the model further showing a number of categories of drugs that reduce aqueous production and hence intraocular pressure.