Use this URL to cite or link to this record in EThOS:
Title: Methodology for the synthesis of 4 or 5-substituted-3-perfluoroalkyl pyrazoles
Author: Oleksik, Laurence
ISNI:       0000 0001 3456 4523
Awarding Body: University of Leicester
Current Institution: University of Leicester
Date of Award: 2004
Availability of Full Text:
Access from EThOS:
Access from Institution:
Initially the perfluoroacylation of a range of commercially available vinyl ethers and conversion of the resulting perfluoroacylated enol ethers to 1-H-pyrazoles via reaction with hydrazine is reported. The selective synthesis of a range of alpha-aryl vinyl ethers using Heck chemistry is then reported. Subsequent perfluoroacylations of the vinyl ethers followed by reaction of the resulting perfluoroacyl enol ethers with hydrazine affords a range of 5-aryl-3-perfluoroalkyl pyrazoles in good yields.;Alternative methodology for the synthesis of 5-aryl-3-perfluoroalkyl pyrazoles is then described in which resin bound esters are converted to vinyl ethers
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available