Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386634 |
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Title: | A biochemical and pharmacological characterisation of some endogenous and exogenous κ opioid ligands | ||||||
Author: | Bell, Katrina Margaret |
ISNI:
0000 0001 3455 5563
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Awarding Body: | Loughborough University of Technology | ||||||
Current Institution: | Loughborough University | ||||||
Date of Award: | 1994 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
An investigation of the interaction of stable opioid/ligands and unstable opioid peptides with opioid receptors in guinea pig brain, guinea pig myenteric plexus and mouse vas deferens has been carried out. The initial aim of the study was to further characterise K opioid receptors, using binding assays and isolated tissue bioassays. The second aim was to determine the true affinity and potency of small dynorphin peptides for the K opioid receptor and to determine if metabolism of the peptides to non K opioid receptor-preferring products contributes to their observed in vitro pharmacology.
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Supervisor: | Not available | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.386634 | DOI: | Not available | ||||
Keywords: | Opioid peptides ; Receptor heterogeneity ; Dynorphin 1-8 ; [Leu5]enkephalin ; Opioid receptors ; Peptide metabolism ; Endopeptidases ; Vas deferens ; Brain | ||||||
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