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Title: Cancer chemotherapy : use of low density lipoproteins as targeting vehicles for treatment
Author: Hynds, Sharyn A.
ISNI:       0000 0001 3585 7598
Awarding Body: University of Glasgow
Current Institution: University of Glasgow
Date of Award: 1986
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The feasibility of using low density lipoprotein(LDL) as a selective drug-targeting vehicle is examined in this thesis. A number of animal tumours are seen to express considerable receptor-mediated uptake of the lipoprotein. The organs likely to suffer during chemotherapy using this carrier, viz. liver and adrenals, are afforded some protection by the administration of bile salts and hydrocortisone respectively. Several methods are employed for incorporating adriamycin, chlorambucil and daunomycin into LDL and the drug-LDL complexes so formed show enhanced cytotoxicity in vitro and in vivo. It is likely that LDL will be a useful targeting vehicle for anticancer agents if the level of drug incorporation can be increased.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: Cancer lipoprotein treatment